Immunobioengineering for Cancer Immunotherapy
Engieered Biomaterials for the Control of Immunity
Biomaterials-based molecular imaging contrast agents
학력
(Ph.D.) KAIST, 공과대학 생명화학공학과, 2002
약력/경력
2014-현재 교수, 성균관대학교, 성균나노과학기술원(SAINT) & 화학공학과
2009-2013 교수, 충남대학교 분석과학기술대학원
2004-2009 선임연구원, 한국생명공학연구원 바이오나노연구센터
2003-2004 선임연구원, 한국전자통신연구원 바이오소자팀
2002-2003 박사후 연수원, 하버드 의과대학 혈액종양 내과
학술지 논문
(2023)
A nanoadjuvant that dynamically coordinates innate immune stimuli activation enhances cancer immunotherapy and reduces immune cell exhaustion.
NATURE NANOTECHNOLOGY.
18,
1
(2022)
Nanoengineered drug delivery in cancer immunotherapy for overcoming immunosuppressive tumor microenvironment.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH.
13,
7
(2022)
Fabrication of Drug-Loaded Calcium Phosphate Nanoparticles: An Investigation of Microbial Toxicity.
JOURNAL OF CLUSTER SCIENCE.
33,
5
(2022)
In Situ-Forming Collagen/poly-gamma-glutamic Acid Hydrogel System with Mesenchymal Stem Cells and Bone Morphogenetic Protein-2 for Bone Tissue Regeneration in a Mouse Calvarial Bone Defect Model.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE.
19,
5
(2022)
Nanoparticle-based delivery strategies of multifaceted immunomodulatory RNA for cancer immunotherapy.
JOURNAL OF CONTROLLED RELEASE.
343,
-
(2021)
The potential adjuvanticity of cavant®soe for foot-and-mouth disease vaccine.
VACCINES.
9,
10
(2021)
Therapeutic efficacy of cancer vaccine adjuvanted with nanoemulsion loaded with TLR7/8 agonist in lung cancer model.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE.
37,
(2021)
Self-assembled hyaluronic acid nanoparticles for osteoarthritis treatment.
BIOMATERIALS.
275,
(2021)
Molecular and Macroscopic Therapeutic Systems forCytokine-Based Cancer Immunotherapy.
Advanced therapeutics.
2100026
(2020)
Chemical Strategies to Enhance the Therapeutic Efficacy of Toll-like Receptor Agonist Based Cancer Immunotherapy.
ACCOUNTS OF CHEMICAL RESEARCH.
53,
10
(2020)
A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy.
BIOMATERIALS.
247,
(2019)
Improved Sensitivity of Intramolecular Strand Displacement Based on Localization of Probes.
ANALYTICAL CHEMISTRY.
91,
23
(2019)
Lyophilizable and Multifaceted Toll-like Receptor 7/8 Agonist-Loaded Nanoemulsion for the Reprogramming of Tumor Microenvironments and Enhanced Cancer Immunotherapy.
ACS NANO.
13,
11
(2019)
A Designer Scaffold with Immune Nanoconverters for Reverting Immunosuppression and Enhancing Immune Checkpoint Blockade Therapy.
ADVANCED MATERIALS.
31,
42
(2019)
Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence.
NATURE COMMUNICATIONS.
10,
(2019)
Topological Transformation-Based Nanobarcoding for Detection and Enumeration of MicroRNAs and Single Nucleotide Polymorphism.
Advanced Biosystems.
3,
7
(2019)
Protein Nanoparticle Fabrication for Optimized Reticuloendothelial System Evasion and Tumor Accumulation.
LANGMUIR.
35,
11
(2019)
Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy.
ADVANCED MATERIALS.
31,
34
(2018)
Targeted cellular delivery of robust enzyme nanoparticles for the treatment of drug-induced hepatotoxicity and liver injury.
ACTA BIOMATERIALIA.
81,
특허/프로그램
CRYOGEL SCAFFOLD CAPABLE OF CONTROLLING DEGREE OF DEGRADATION
AND SOFT BIO-INTEGRATED DEVICE IN WHICH DRUG MODULATING
IMMUNOSUPPRESSIVE ACTION IN SOLID MICROENVIRONMENT IS LOADED IN
SAME SCAFFOLD.
16/954,324.
20230112.
미국
THERMOSENSITIVE IONIC COMPOSITE, PREPARING METHOD THEREOF, AND
BIODEGRADABLE COMPOSITION CONTAINING THE SAME.
14/828,876.
20180828.
미국
재구성 인공 암세포, 이의 제조방법, 및 이를 포함하는 항암조성물.
10-2017-0000357.
20180523.
대한민국
폴리감마글루탐산 함유 하이드로겔 및 이를 포함하는 의료용 접착제 및 지혈제.
10-2016-0026130.
20180427.
대한민국
약물 전달용 조성물 및 이의 제조방법.
10-2016-0116955.
20171201.
대한민국
약물전달 조성물, 및 감염질환 진단 및 치료용 조성물.
10-2015-0050833.
20161007.
대한민국
암 백신 조성물 및 이의 제조 방법.
10-2015-0050843.
20160804.
대한민국
생체친화성 음이온 고분자 기반 약물 전달용 조성물 및 이의 제조 방법.
10-2014-0112655.
20160802.
대한민국
아주번트 조성물 및 백신 조성물의 제조 방법.
10-2015-0073826.
20160215.
대한민국
면역보조제 및 이를 포함하는 백신 조성물.
10-2014-0195268.
20160112.
대한민국
면역자극 조성물, 이의 제조 방법, 및 이를 포함하는 면역요법 조성물.
10-2014-0195270.
20160112.
대한민국
아주번트 조성물, 이의 제조 방법, 및 이를 포함하는 백신 조성물.
10-2014-0193994.
20160112.
대한민국
아주번트 조성물, 이의 제조방법, 및 이를 포함하는 백신 조성물.
10-2014-0195269.
20151210.
대한민국
온도감응형 이온성 복합체, 이의 제조 방법, 및 이를 포함하는 생분해성 조성물.
10-2014-0107045.
20151116.
대한민국
중-대동물 수술가이드용 근적외선 형광 영상장비 및 이를 이용한 이미지화 및 수술가이드 방법.
1020130015119.
20150429.
대한민국
활성물질을 담지할 수 있는 표면 딤플구조를 갖는 미립자 및 그 제조방법.
1020130046966.
20141216.
대한민국
음이온성 고분자와 양이온성 고분자 이온복합체 기반 고감도 자기공명영상 나노조영제 및 이의 제조방법(Sensitive MRI Contrast Nano Agents Based Ionic Complex Containing Anionic and Cationic Polymer and Preparing Method Thereof).
10-2011-0031665.
20140515.
대한민국
항체와 나노입자를 세포 내로 동시에 전달할 수 있는다기능성 단백질(Multifunctional Protein Simultaneous Delivering Antibodies and Nanoparticles).
10-2007-0074759.
20091102.
대한민국
수상/공훈
국내외 화학관련 학회 정회원 (한국화학공학회, 대한화학회 등)
대한면역학회 학술위원
국제학술지 Editorial Board
학술회의논문
(2023)
Materials for kinetic immune modulation reshape immunity.
2023 International Conference of the Korean Society of Pharmaceutical Science and Technology.
대한민국
(2023)
Immune Designer for Dynamic Tailoring of Innate Immunity.
2023년 한국고분자학회 추계 정기총회 및 학술대회.
대한민국
(2023)
Dynamic Coordination of Innate Immunity for Enhanced Cancer Immunotherapy and Reduction of Immune Cell Exhaustion by Using Kinetically Activating Nanoadjuvant.
Seventh CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference.
이탈리아
(2023)
Dynamic Coordination of Innate Immunity for Enhanced Cancer Immunotherapy and Reduction of Immune Cell Exhaustion by Using Kinetically Activating Nanoadjuvant.
KAI International Meeting 2023.
대한민국
(2023)
Time-controled DC activation for enhanced cancer immunotherapy.
KAI International Meeting 2023.
대한민국
(2023)
Engineered Macrophages Anchored with Toll-like Receptor 7/8 Agonist by Click Chemistry Enhance Antitumor Immunity.
KAI International Meeting 2023.
대한민국
(2023)
Reprogramming TME with immunostimulator and blockade of SIRPα-CD47 axis enhances antitumor innate immunity.
KAI International Meeting 2023.
대한민국
(2023)
Designer Vaccine Adjuvant/immunomodulators for Injectious Disease.
대한바이러스 학회 연구회 연합 정기 학술대회.
대한민국
(2022)
Controlling Chemoimmunotherapy-induced Immunosuppression by Assemblable
Immune Modulating Nanosuspension Combined with Supra-adjuvant.
2022 한국생물공학회 추계학술발표대회 및 국제심포지엄.
대한민국
(2022)
Novel vaccine adjuvants empowered by coded signal integration.
바이러스연구포럼.
대한민국
(2022)
Nanoengineered Synthetic Immune Niches for Enhanced Cancer Immunotherapy.
2022 춘계고분자학술대회.
대한민국
(2021)
Modulation of Tumor Microenvironment by a Designer Scaffold with Immune Checkpoint Blockade Enhance Cancer Immunotherapy.
2021년 고분자학회 춘계학술대회.
대한민국
(2021)
Engineered Macrophage via Click Chemistry Enhances Tumor Targeting and Remodels Immunosuprressive Tumor Microenvironment.
2021년 한국고분자학회 춘계학술대회.
대한민국
(2020)
Synthetic Immune Niches for Cancer Immunotherapy.
Internationa annual meeting of Korean Tissue Engineering and Regenerative Medicine Society.
대한민국
(2020)
Reprogramming of immunosuppressive tumor microenvironments by multifunctional nanoemulsion and enhance immune checkpoint blockade therapy.
AACR2020.
미국
(2019)
Synthetic Immune Niches for the Modulation of Immunosuppressive Tumor Microenvironments and Enhancing Cancer Immunotherapy.
종양이형성 및 네트워크 제어 연구센터 2019 연례 심포지엄.
대한민국
(2019)
Synthetic Immune Niches for the Modulation of Tumor Immunosuppressive Microenvironments.
2019 KSMI-KSNM Integration Event Symposium on Molecular Imaging and Nanomedicine.
대한민국
(2019)
Toll-Like receptor 7/8 agonist-loaded Nanoemulsion Vaccine Adjuvant for the Enhanced Cancer Immunotherapy.
2019 Modern Vaccines Adjuvants & Delivery systems.
스위스
(2019)
Nanoengineered platforms to modulate tumor immune microenvironments.
2019 UKC.
미국
(2018)
Beyond Adjuvants: Vaccines for Cancer Immunotherapy and Infectious Disease.
International Society for VACCINES 2018 congress.
미국
